The science behind regulating glucose levels

Clinically-proven active ingredients

Anti-Spike's unique formula, with a combination of patented clinically-proven ingredients, make it the best, most powerful natural supplement to reduce glucose spikes.

Read the clinical studies

4 premium ingredients protect you from glucose spikes

Mulberry leaf

White mulberry leaf (Reducose®, 250mg) contains DNJ, an alpha-glucosidase inhibitor which lets sugar molecules of your meal pass through to your microbiome without being absorbed into your bloodstream. This leads to a 40% reduction in the glucose spike of the meal.

Citrus polyphenols

This lemon extract (Eriomin®, 250mg) contains eriocitrin and naringenin, natural flavonoids that regulate inflammation, increase antioxidant capacity and GLP-1. This means better natural defenses, lower inflammation, and feeling naturally more satiated.

Antioxidants

This is a concentrated blend of 100mg of vegetable extracts to provide natural polyphenols to your body. The vegetables are: purple carrot, spinach, broccoli, cabbage, asparagus, zucchini, cucumber, and artichoke. With this ingredient you will harness powerful benefits of vegetables on your health.

Cinnamon extract

Cinnamon is the most widely studied glucose-improving plant. It helps your body uptake extra glucose as it arrives into your bloodstream, and has been proven to combat insulin resistance. Anti-Spike contains 85mg of an extremely high quality extract of cinnamon.

A quick note: Anti-Spike is not recommended if you are pregnant or breastfeeding, if you are taking antidiabetic medication, or in cases of biliary obstruction or other biliary function disorders. Also Anti-Spike is not recommended if you have a known allergy to balsam of Peruor Asteraceae. People with hypothyroidism or thyroid treatment should consult their doctor. Please check with your doctor before you take Anti-Spike.
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  • 100% Natural ingredients
  • 100% Vegan
  • 100% Traceability
  • Sugar-Free
  • Gluten-Free
  • Dairy-Free and Soy-Free
  • Made in France
  • Sustainable Packaging

What to expect with Anti-Spike

WEEK 1

Glucose spikes up to 40% smaller

After a few days of Anti-Spike, you will feel less desire to eat sugar after your meals. The “crash” after eating will also lessen. You will have more energy to get what you want done.

–40% glucose spike on your meal
–30% insulin spike on your meal

MONTH 2

Glucose, insulin, and HbA1c improve

After 2 months of daily Anti-Spike you will see whole-body results: easier fat burn, sustained energy, clearer brain, and less sugar addiction. 

−8 mg/dL fasting glucose (−0.47 mmol/L) 
−2.92 mmol/mol HbA1c
−0.58 μIU/mL fasting insulin

MONTH 3

GLP-1 increases naturally, gut microbiome improves

Deep change is happening through your gut: as it gets healthier, it produces more GLP-1. You feel more satiated. You will get further improvements in markers of overall health as well. 

+15 to 17% GLP-1 increase after 3 months 
−11% HOMA-IR after 12 weeks

The studies behind the formula

The ingredients in Anti-Spike were chosen because of the gold-standard clinical trials backing their efficacy and safety.

  • Study: Systematic review and meta-analysis of randomized clinical trials, on the effect of Mulberry leaf or Mulberry leaf extract on glycemic traits in adults, 615 participants.Meta-analysis showed a significant reduction in fasting blood glucose by −8.5 mg/dL, HbA1c by −2.92 mmol/mol, and fasting insulin by −0.58 μIU/mL.

    2023
    Systematic review and meta-analysis of randomized clinical trials    , on the effect of Mulberry leaf or Mulberry leaf extract on glycemic traits in adults, 615 participants.

    Meta-analysis showed a significant reduction in fasting blood glucose by −8.5 mg/dL, HbA1c by −2.92 mmol/mol, and fasting insulin by −0.58 μIU/mL.

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  • Study: Randomized placebo-controlled crossover study, on the effects of Mulberry leaf extract in people with type 2 diabetes, 30 participants.The Mulberry Leaf Extract blend significantly reduced glucose iAUC at 1 h (- 20%, p < 0.0001), 2 h (- 17%, p = 0.0001), and 3 h (- 15%, p = 0.0032).

    2023
    Randomized placebo-controlled crossover study, on the effects of Mulberry leaf extract in people with type 2 diabetes, 30 participants.

    The Mulberry Leaf Extract blend significantly reduced glucose iAUC at 1 h (- 20%, p < 0.0001), 2 h (- 17%, p = 0.0001), and 3 h (- 15%, p = 0.0032).

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  • Study: Randomized double-blind placebo-controlled study on the effect of Mulberry leaf extract on glucose and insulin responses in healthy subjects, 38 participants.Glucose iAUC (- 42%), insulin iAUC (- 40%), peak glucose (p < 0.001) and peak insulin (- 41%) from baseline were significantly lower (all p =< 0.001) compared with placebo.

    2021
    Randomized double-blind placebo-controlled study on the effect of Mulberry leaf extract on glucose and insulin responses in healthy subjects, 38 participants.

    Glucose iAUC (- 42%), insulin iAUC (- 40%), peak glucose (p < 0.001) and peak insulin (- 41%) from baseline were significantly lower (all p =< 0.001) compared with placebo.

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  • Study: Randomized double-blind placebo-controlled study on the effect of 3 different doses of Mulberry leaf extract on glucose and insulin responses in healthy subjects, 37 participants.Glucose iAUC (-32%) and insulin iAUC (-38%) from baseline were significantly lower (all p=<0.002) compared with placebo.

    2024
    Randomized double-blind placebo-controlled study on the effect of 3 different doses of Mulberry leaf extract on glucose and insulin responses in healthy subjects, 37 participants.

    Glucose iAUC (-32%) and insulin iAUC (-38%) from baseline were significantly lower (all p=<0.002) compared with placebo.

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  • Study: Randomized double-blind placebo-controlled study on the effect of Eriomin® on hyperglycemia, GLP-1 and gut microbiota in individuals with prediabetes, 29 participants.200mg/d significantly increased GLP-1 (+22%), reduced hyperglycemia (-6%)(p<0.05), reduced the growth of microorganisms associated with intestinal dysbiosis and increased the abundance of beneficial bacteria.

    2023
    Randomized double-blind placebo-controlled study on the effect of Eriomin® on hyperglycemia, GLP-1 and gut microbiota in individuals with prediabetes, 29 participants.

    200mg/d significantly increased GLP-1 (+22%), reduced hyperglycemia (-6%)(p<0.05), reduced the growth of microorganisms associated with intestinal dysbiosis and increased the abundance of beneficial bacteria.

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  • Study: Double-blind, randomized, placebo-controlled crossover study on Eriomin® reducing hyperglycemia in individuals with prediabetes, 30 participants.200 mg/d significantly decreased blood glucose (-5%), homeostasis model assessment of insulin resistance (-11%), [...] but increased GLP-1 by (17%) (P≤ .05).

    2022
    Double-blind, randomized, placebo-controlled crossover study on Eriomin® reducing hyperglycemia in individuals with prediabetes, 30 participants.

    200 mg/d significantly decreased blood glucose (-5%), homeostasis model assessment of insulin resistance (-11%), [...] but increased GLP-1 by (17%) (P≤ .05).

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  • Study: Study in a dynamic microbiome model on the combination of the nutraceutical Eriomin® with a common diabetes medication for improving pre-diabetes.After treatment with Eriomin® plus a common diabetes medication, a significant increase in acetate and butyrate production was observed.

    2022
    Study in a dynamic microbiome model on the combination of the nutraceutical Eriomin® with a common diabetes medication for improving pre-diabetes.

    After treatment with Eriomin® plus a common diabetes medication, a significant increase in acetate and butyrate production was observed.

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  • Study: Double-blind, randomized, placebo controlled study on the effectiveness of Eriomin® in managing hyperglycemia and reversing prediabetes, 103 participants.Reduction of blood glucose (-5%), insulin resistance (-7%), glucose intolerance (-7%), [...] increase of GLP-1 (+15%), [...] and antioxidant capacity (+6%).

    2019
    Double-blind, randomized, placebo controlled study on the effectiveness of Eriomin® in managing hyperglycemia and reversing prediabetes, 103 participants.

    Reduction of blood glucose (-5%), insulin resistance (-7%), glucose intolerance (-7%), [...] increase of GLP-1 (+15%), [...] and antioxidant capacity (+6%).

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  • Study: Two randomized crossover studies on the effect of whey protein and Mulberry leaf extract on postprandial glycemia.250 mg mulberry leaf extract was more efficient if it was taken together with a complete 510 kcal meal (−34%, p < 0.001) rather than ingested 5 min before (−26%, p = 0.002).

    2022
    Two randomized crossover studies on the effect of whey protein and Mulberry leaf extract on postprandial glycemia.

    250 mg mulberry leaf extract was more efficient if it was taken together with a complete 510 kcal meal (−34%, p < 0.001) rather than ingested 5 min before (−26%, p = 0.002).

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  • Study: 2022Randomized repeat-measure design study on the effect of Mulberry leaf extract in reducing the glycemic index of white bread.The addition of mulberry leaf extract significantly reduced the total blood glucose rise after ingestion of white bread over 120 minutes, and reduced the GI value of white bread in a dose-effect relationship.

    2022
    Randomized repeat-measure design study on the effect of Mulberry leaf extract in reducing the glycemic index of white bread.

    The addition of mulberry leaf extract significantly reduced the total blood glucose rise after ingestion of white bread over 120 minutes, and reduced the GI value of white bread in a dose-effect relationship.

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  • Study: Randomized open-label 7-cycle self-controlled crossover study on the effect of Mulberry leaf extract on the glycemic indexes of dietary carbohydrates, 15 participants.Mulberry leaf extract reduced the Glycemic Indexes for maltose, sucrose, maltodextrin, and glucose by 53.11%, 33.51%, 31.00%, and 8.12%, respectively.

    2018
    Randomized open-label 7-cycle self-controlled crossover study on the effect of Mulberry leaf extract on the glycemic indexes of dietary carbohydrates, 15 participants.

    Mulberry leaf extract reduced the Glycemic Indexes for maltose, sucrose, maltodextrin, and glucose by 53.11%, 33.51%, 31.00%, and 8.12%, respectively.

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  • 2017
    Randomized double-blind placebo-controlled study on the effect of Mulberry extract on healthy adults, 37 participants.

    The difference in the glucose pIAUC compared with placebo was -6.1%, -14.0%, and -22.0% respectively. The difference in the insulin pIAUC compared with placebo was -9.7%, -23.8% and -24.7% respectively.

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  • Study: Randomized placebo-controlled study to determine whether cinnamon improves blood glucose and lipid levels in people with type 2 diabetes, 60 participants.After 40 days, all three levels of cinnamon reduced the mean fasting serum glucose (18-29%); [...] no significant changes were noted in the placebo groups.

    2003
    Randomized placebo-controlled study to determine whether cinnamon improves blood glucose and lipid levels in people with type 2 diabetes, 60 participants.

    After 40 days, all three levels of cinnamon reduced the mean fasting serum glucose (18-29%); [...] no significant changes were noted in the placebo groups.

    Read Study

  •
  • Effect on Anti-Spike on glucose spikes
  • List of ingredients in Anti-Spike supplement
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